La Piedra is the main physical-demand decision
The staircase is long and steep enough that it should be optional, not a test everyone in the group has to pass. Build a no-climb plan if stairs are a poor fit.
Reservoir activities
Use established operators, wear the safety equipment provided, and follow the operator's weather and loading decisions. Do not jump or swim in unfamiliar water without understanding depth, traffic and access back out.
Mobility planning
Central town is more manageable than the rock, but uneven surfaces, slopes and busy pedestrian areas can still matter. Private transport or a flexible vehicle becomes more useful when someone in the group needs fewer transfers or more control over stops.
Simple personal-safety habits
Use the same urban travel habits you would use elsewhere in Colombia: keep valuables low-key, watch your phone in crowded areas, know how you are returning before late in the day, and ask your accommodation or operator when local conditions are unclear.